Development of Novel Peptide Inhibitors to Bag-1 ebook

Development of Novel Peptide Inhibitors to Bag-1 by Brunn Jonathan

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Author: Brunn Jonathan
Page Count: 92 pages
Published Date: 28 Feb 2014
Publisher: LAP Lambert Academic Publishing
Publication Country: United States
Language: English
ISBN: 9783846543023
File Name: Development.of.Novel.Peptide.Inhibitors.to.Bag-1.pdf
Download Link: Development of Novel Peptide Inhibitors to Bag-1
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One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book it to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named 'Contact" and experimentally verified via Biacore (c) binding assays.

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